為什麼子宮內膜簡單刮一下就可以增加胚胎著床？增加試管嬰兒成功懷孕呢？ion

2014.06.07

 為什麼子宮內膜簡單刮一下就可以增加胚胎著床？增加試管嬰兒成功懷孕呢？ion

 
2014年3月有一份登在《人類生殖期刊》的研究，他們發現原來子宮內膜細胞有各式各樣的離子通道，這份研究來自於香港中文大學，他們找到了共有14種離子通道，包括鈉離子、氯離子、鈣離子、囊狀纖維化轉移膜離子、鉀離子等，都跟子宮內膜接受胚胎度有關。
 
研究中發現，這些離子通道在調整子宮內膜接受胚胎時，扮演非常神祕的正面角色，一旦這些離子通道沒˙有辦法在胚胎著床的時候展現，極可能讓胚胎著床失敗；這個現象也解釋了為什麼很頂級優質的胚胎、染色體檢查完全正常的胚胎，還是沒有辦法100％著床，只有64.7％著床，原來子宮內膜要不要接受一個胚胎，也是非常重要的一環。
 
子宮內膜刺激術，試管嬰兒懷孕率高達百分之一百的秘密武器！
 
 
 
http://www.youtube.com/watch?v=LO11XyoQS0E&google_comment_id=z13vglt4zzf2t132q23dgjqx5yi5c32xy04&google_view_type#gpluscomments
子宮內膜刺激術，試管嬰兒懷孕率高達百分之一百的秘密武器！
 
 
 
Hum Reprod Update. 2014 Mar 2. [Epub ahead of print]
Ion channels in the endometrium: regulation of endometrial receptivity and embryo implantation.
Ruan YC1, Chen H, Chan HC.
Author information
 
Abstract
BACKGROUNDAlthough embryo implantation is a prerequisite for human reproduction, it remains a poorly understood process. The molecular mechanisms regulating endometrial receptivity and/or embryo implantation are still largely unclear
.METHODSPubmed and Medline literature databases were searched for articles in English published up to December 2013 with relevant keywords including 'endometrium', 'Na+, Cl-, K+, or Ca2+ channels', 'ion channels', 'endometrial receptivity', 'blastocyst implantation' and 'embryo implantation'
.RESULTSAt the time of writing, more than 14 types of ion channels, including the cystic fibrosis transmembrane conductance regulator, epithelial sodium channel and various Ca2+ and K+ channels, had been reported to be expressed in the endometrium or cells of endometrial origin. In vitro and/or in vivo studies conducted on different species, including rodents, pigs and humans, demonstrated the involvement of various ion channels in the process of embryo implantation by regulating: (i) uterine luminal fluid volume; (ii) decidualization; and (iii) the expression of the genes associated with implantation. Importantly, abnormal ion channel expression was found to be associated with implantation failure in IVFpatients.
 
CONCLUSIONS
Ion channels in the endometrium are emerging as important players in regulating endometrial receptivity and embryo implantation. Abnormal expression or function of ion channels in the endometrium may lead to impaired endometrial receptivity and/or implantation failure. Further investigation into the roles of endometrial ion channels may provide a better understanding of the complex process of embryo implantation and thus reveal novel targets for diagnosis and treatment of implantation failure.