林志玲冷凍9顆卵子夠嗎？不夠！17顆才夠！CRYO

2014.06.13

 林志玲冷凍9顆卵子夠嗎？不夠！17顆才夠！CRYO

 
 
媒體報導好像林志玲去台大冷凍卵子，
當然林志玲否認，我們尊重林志玲的說法，
 
但林志玲以40歲的女人冷凍9顆卵子夠嗎？
 
這裡有一個公式可以利用預估你要冷凍幾顆卵子才夠生一個小孩，
分母是平均幾顆卵子能形成囊胚的比率，比如4個卵子
 
分子是(該年齡群囊胚及胚胎切片檢查染色體正常的比率比如40歲為41.8%)x乘以(染色體正常囊胚的活產率比如55%)，這樣相除可以得到能有幾顆卵子，
4/0.418x0.55=17.4
 
以林志玲的40歲，我從算至少要有17顆，
林志玲說她想生龍鳳胎
因此一個女人要冷凍幾顆卵子？要看年紀，而不是只有冷凍就是買了保險。穏生的
 
 
Age (y) Oocytes retrieved (μ ± SEM) Cohorts of embryos evaluated (n) No. of biopsies evaluated (n) Euploid Aneuploid      
n Percentage of total n Percentage of total          
22 23.5 ± 3.5 9 72 40 55.6 32 44.4  
23 19.3 ± 1.7 12 76 45 59.2 31 40.8  
24 21.5 ± 2.1 13 79 57 72.2 22 27.8  
25 12.9 ± 1.1 17 90 50 55.6 40 44.4  
26 15.1 ± 1.1 29 175 132 75.4 43 24.6  
27 16.2 + 0.6 36 240 175 72.9 65 27.1  
28 13.0 ± 0.7 57 335 259 77.3 76 22.7  
29 13.9 ± 0.4 106 585 464 79.3 121 20.7  
30 12.9 ± 0.4 126 802 616 76.8 186 23.2  
31 13.9 ± 0.3 164 862 595 69.0 267 31.0  
32 11.1 ± 0.2 193 1,023 705 68.9 318 31.1  
33 13.9 ± 0.4 231 1,324 913 69.0 411 31.0  
34 13.7 ± 0.4 221 1,156 794 68.7 362 31.3  
35 11.6 ± 0.3 226 1,222 800 65.5 422 34.5  
36 12.8 ± 0.3 267 1,284 828 64.5 456 35.5  
37 10.1 ± 0.3 257 1,153 662 57.4 491 42.6  
38 8.7 ± 0.2 280 1,123 585 52.1 538 47.9  
39 10.5 ± 0.2 272 1,008 475 47.1 533 52.9  
40 11.2 ± 0.3 249 953 398 41.8 555 58.2  
41 9.2 ± 0.3 234 750 233 31.1 517 68.9  
42 8.7 ± 0.2 150 453 113 24.9 340 75.1  
43 6.0 ± 0.3 79 217 36 16.6 181 83.4  
44 5.7 ± 0.2 41 85 10 11.8 75 88.2  
45 8.0 ± 0.4 22 39 4 15.7 35 84.3  
46 11.8 ± 0.5 4 43 12 27.9 31 72.1  
47 6.3 ± 0.3 4 17 0 0.0 17 100.0  
48 2 1 1 0 0.0 1 100.0  
49 4 1 2 0 0.0 2 100.0  
Total   3,301 15,169 9,001   6,168    
                 
 
How many eggs should I freeze?
Edward J. Nejat, M.D., M.B.A.
, 
Janelle Luk, M.D.
 , 
John Zhang, M.D., Ph.D., H.C.L.D.
New Hope Fertility Center, New York, New York
Published Online: June 04, 2014
April 17, 2014
Publication stage: In Press Corrected Proof
 
  •  
  •  
 
To the Editor:
We read with great interest the recent publication by Franasiak et al. (1). They retrospectively report the largest published series to date of blastocysts screened for aneuploidy. It brings to mind a question that often is presented to the infertility specialist with regard to elective oocyte cryopreservation to defer childbearing. How many oocytes should be frozen at a given age to obtain one live birth? Using data from the Franasiak et al. article, additional data from the same subjects, and some arithmetic extrapolation, perhaps we can make an informed estimate of this number as follows:
 
 
Of course, the majority of the population studied was presumably infertile, therefore the number of oocytes required per live birth for women seeking elective oocyte cryopreservation who are not infertile would quite possibly be fewer. This approach could assist us in guiding our patients when counseling them in response to a question that we will inevitably hear more and more frequently in the coming years.
Reference
  • Franasiak, J.M., Forman, E.J., Hong, K.H. et al. The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening.Fertil Steril. 2014; 101: 656–663.e1
  •  
  •   
  •   
  •   
  •   
 
© 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.