胚胎染色體越多異常越不容易形成囊胚,越不容易聽到胎兒心跳

2014.06.14

 胚胎染色體越多異常越不容易形成囊胚,越不容易聽到胎兒心跳  fhb

有一份研究登在2014年的05月30日人類生殖期刊，他們發現染色體的異常
可能一個染色體異常，
可能兩個染色體異常，
三個染色體異常，
 
但在染色體異常方面，如果說有一個染色體異常，兩個染色體異常，三個染色體異常，形成囊胚的比率會越來越低，
在這個研究中，發現凡是有染色體正常的，形成囊胚期胚胎的比率為76.30%，而聽到心跳56.7%，
染色體異常有形成囊胚是25.5%可以聽到胎兒心跳17.7%
 
所以這個報告可以告訴我們說有些染色體異常，
它可以到心跳後來到沒有心跳，當然這個研究也突顯了一個問題在染色體異常一個兩個三個形成囊胚的比率，從50%降到40%降到20%，可見越多染色體異常月不容易形成囊胚越不容易聽到心跳。
 
 
Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors
Objective
To test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with array-comprehensive genomic hybridization (aCGH).
Design
Retrospective cohort study.
Setting
University-affiliated institution.
Patient(s)
Forty-one patients with 48 in vitro fertilization (IVF) cycles and 385 embryos that underwent cleavage-stage preimplantation genetic screening (PGS) with aCGH at the Continuum Reproductive Center between January 2010 and September 2013.
Intervention(s)
None.
Main Outcome Measure(s)
Probability of blastocyst and/or fully expanded or hatching blastocyst (FEHB) progression depending on number of chromosomal abnormalities.
Result(s)
Euploid embryos are twice as likely to progress to blastocyst and three times as likely to progress to FEHB than aneuploid embryos: 76% versus 37% and 56% versus 18%, respectively. For every additional chromosomal abnormality, the likelihood of progressing to the blastocyst stage decreases by 22% and the likelihood of progressing to FEHB decreases by 33%.
Conclusion(s)
Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst and FEHB stages. There is a linear decrease in probability of blastulation with the increasing number of chromosomal abnormalities.