男性荷爾蒙是卵巢功能弱的救星？testosterone 對於卵巢功能低或高齡不孕，我們常會因為卵巢功能低而導致取卵數不多，因而使懷孕率降下降。醫學上也曾經常試過DHEA、肌醇、或提高打排卵針得劑量、或增加使用生長激素。但什麼才是最有效的呢？ 幾年前有人提出，使用經皮膚塗抹男性荷爾蒙凝膠或貼男性荷爾蒙貼片，其機轉是：利用體內男性荷爾蒙濃度的增加，將功能不佳的卵巢推向多囊性卵巢體質，這幾年下來有多達221篇的研究出爐。 2014年7月有一份研究做了me

2014.06.21

 男性荷爾蒙是卵巢功能弱的救星？testosterone 

   
    對於卵巢功能低或高齡不孕，我們常會因為卵巢功能低而導致取卵數不多，因而使懷孕率降下降。醫學上也曾經常試過DHEA、肌醇、或提高打排卵針得劑量、或增加使用生長激素。但什麼才是最有效的呢？
    
    幾年前有人提出，使用經皮膚塗抹男性荷爾蒙凝膠或貼男性荷爾蒙貼片，其機轉是：利用體內男性荷爾蒙濃度的增加，將功能不佳的卵巢推向多囊性卵巢體質，這幾年下來有多達221篇的研究出爐。
    
      2014年7月有一份研究做了meta-analysis 綜合分析，把這221篇研究做出meta-analysis 統計：經皮膚塗抹男性荷爾蒙凝膠可以
      增加1.36倍取卵數目
     增加2.01倍的懷孕率，
     也就是說，經由皮膚塗抹男性荷爾蒙已目前的研究來看是有效的，而且在所有卵巢功能低下改善的解決方案中，是有效的！
      
      
Effect of pretreatment with transdermal testosterone on poor ovarian responders undergoing IVF/ICSI: A meta-analysis.
 
Abstract
In order to identify and describe the effectiveness of transdermal testosterone pretreatment on poor ovarian responders, MEDLINE, EMBASE, the Cochrane library and the Chinese biomedical database were searched for randomized controlled trials (RCTs). Three RCTs, which compared the outcomes of female pretreatment with transdermal testosterone prior to in vitrofertilization/intracytoplasmic sperm injection (IVF/ICSI) with those of control groups, were included in the present review. The three RCTs enrolled a total of 221 randomized subjects. The meta-analysis revealed that females who received transdermal testosterone treatment prior to theirIVF/ICSI cycle had a 
two-fold increase in live birth rate [risk ratio (RR)=2.01, 95% confidence interval (CI) 1.03-3.91], clinical pregnancy rate (RR=2.09, 95% CI 1.14-3.81)
 and a significantly more oocyte retrieved [mean difference (MD)=1.36, 95% CI 0.82-1.90]. 
The current findings provide evidence that pretreatment with transdermal testosterone may improve the clinical outcomes for poor ovarian responders undergoing IVF/ICSI
 
 However, the results should be interpreted with caution due to the small sample size of the studies used and the heterogeneities. Further good quality RCTs would be needed to reach further conclusions.